Molecular Mechanisms of Prion Pathogenesis
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of prion pathogenesis.
Prion diseases are infectious neurodegenerative diseases occurring in humans and animals with an invariably lethal outcome. One fundamental mechanistic event in prion diseases is the aggregation of aberrantly folded prion protein into large amyloid plaques and fibrous structures associated with neurodegeneration. The cellular prion protein (PrPC) is absolutely required for disease development, ...
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In humans, prion diseases occur with unique aetiology as sporadic, genetic or infectious disorders. Sporadic cases of prion diseases, which account for the majority of casualties (up to 85% of all cases), are of unknown origin; the genetic forms are less frequent (up to 15%), while the infectious cases are extremely rare with an incidence of less than 1% (Prusiner, 2001). Creutzfeldt-Jakob dise...
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ژورنال
عنوان ژورنال: Annual Review of Pathology: Mechanisms of Disease
سال: 2008
ISSN: 1553-4006,1553-4014
DOI: 10.1146/annurev.pathmechdis.3.121806.154326